Did you know that you can go to My Kleenex Tissue and design your own tissue box?
For the low, low price of $4.99 each plus shipping.
Yes, I checked out their designs (you could make a "Happy Birthday" tissue box for someone! What kind of message does that send?), and you can even upload your own pictures and art work (I blow my nose on you?).
But considering I buy my Kleenex in bulk, on sale, ideally with a coupon as well, I don't think this is coming to my house any time soon.
(OK, in their defense, you could cut out the bottom of the box and make it refillable. But it seems like it should come that way for that price.)